Barclays Premier League
Venue: Old Trafford Date: Monday, 16 August Kick-off: 2000 BST
Coverage: BBC Sport website, BBC Radio 5 live, local radio and live on Sky Sports 1
Manchester United remain without long-term injury victims Owen Hargreaves and Anderson, with both midfielders absent with knee injuries.
Centre-back Rio Ferdinand is also out with a knee problem.
Newcastle striker Andy Carroll has been declared fit to lead the line, while former Red Devil Alan Smith is expected to shake off an ankle injury.
But Leon Best, Danny Simpson (both ankle), Steven Taylor (shoulder) and Dan Gosling (knee) will all miss out.
Manchester United
Injured: Anderson, Ferdinand, Hargreaves (all knee)
Newcastle
Doubtful: Smith (ankle)
Injured: Best & Simpson (both ankle), Gosling (knee), S Taylor (shoulder)
Newcastle mark their return to the top-flight with a daunting trip to Old Trafford, where they will be hoping for a first win over Manchester United since September 2001.
That season began with Sir Alex Ferguson announcing his intention to retire from football management at the end of the campaign, and ended with Newcastle in fourth spot, one place behind the Manchester club.
Fast-forward nine years and while Newcastle have been in steady decline, Ferguson is still at Old Trafford, his appetite for trophies unabated. Last season's final-day title disappointment will have only strengthened the Red Devils' hunger for silverware, and with no significant player exits and the addition of exciting striker Javier Hernandez in attack, United look well-placed to mount another serious title bid.
Newcastle's reaction to Premier League relegation in May 2009 could not have been better. Chris Hughton's side won the Championship with ease, and with the likes of Jose Enrique, Jonas Gutierrez and the experienced Kevin Nolan, they look well-equipped to avoid an immediate return to the second tier.
Newcastle's last Premier League campaign also started against Manchester United, a 1-1 draw at Old Trafford. While the Magpies would take a repeat result on Monday, they will be praying the rest of the season plays out differently.
Head-to-head
• Man Utd have won 12 of their last 15 encounters with Newcastle.
• Newcastle's last win at Old Trafford was in February 1972.
• The Magpies have scored only nine times in 16 Premier League visits to Old Trafford.
Manchester United
• Manchester United have won only one of their last three opening-day fixtures, 1-0 last season against Birmingham City.
• This is the fifth season in succession that United have kicked-off the new season at Old Trafford, and the ninth time in 11 years.
• The Red Devils have lost their opening game only once in the last 14 years - a 1-0 defeat at Chelsea in 2004.
Newcastle
• Newcastle have won only three of their last 11 opening-day Premier League fixtures.
• The Magpies converted 20% of their chances into goals last season, the highest proportion in the Championship.
• Goalkeeper Steve Harper had the best saves-to-shots ratio in the Championship (80%), while Edwin van der Sar had the best rate in the Premier League (81%).
- LAST SEASON'S LEADING GOALSCORERS
Manchester United
Rooney: 34 goals (26 league); Berbatov: 12 goals (12 league)
Newcastle
Carroll: 19 goals (17 league); Nolan: 18 goals (17 league)
Referee: Chris Foy
Assistant referees: Robert Pollock & Andy Garratt
Fourth official: Lee Mason
- LAST LEAGUE MATCH LINE-UPS
Manchester United (W4-0 v Stoke, h): Van der Sar; Neville, Evra, Ferdinand, Vidic, Giggs, Nani, Scholes (Gibson 62), Fletcher, Berbatov (Macheda 62), Rooney (Park 77).
Subs not used: Foster, O'Shea, Evans, Park, Carrick.
Newcastle (W1-0 v QPR, a): Krul; Coloccini, Williamson, Simpson, Taylor, Barton, Guthrie (Vuckic 79), Routledge, Smith, Best (Lovenkrands 54), Ameobi (Carroll 79).
Subs not used: Harper, Nolan, Pancrate, Donaldson.
From BBC